Endocrine Abstracts

Introduction: Brown tumor is a rare benign bone lesion with incidence ranging from 1.5% in primary hyperparathyroidism to 13% in secondary hyperparathyroidism. Common sites of involvement are pelvis, femur and ribs, but may appear in any bone. Since the incidence of thyroid disease is higher among patients with hyperparathyroidism than the general population, these lesions must be distinguished from metastases from thyroid carcinoma.We present a patient ...

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

Introduction: Recent studies showed that post-menopausal osteoporosis and weight gain starts at the perimenopause stage, a period characterized by relatively stable estrogen and rising FSH levels. FSH is found to be associated with adiposity in women, which is also a great risk factor for type 2 DM. There is also a sharp increase in visceral adiposity during this life stage, which coincides with the emergence of disrupted energy balance and reduced physical activity. There is ...

Introduction: Patients with hypogonadism are at increased risk for cardiovascular diseases. Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are hematological indices that are surrogate markers of adverse cardiovascular outcomes. This study investigated the platelet count, MPV levels, PLR, and NLR in patients with congenital hypogonadotrophic hypogonadism (CHH) and also studied the effect of testosterone replacement thera...

Objective: In differentiated thyroid carcinoma (DTC), TSH suppression with levothyroxine (L-T4) is a standard treatment for reducing tumor recurrence after total thyroidectomy. This study aims to evaluate the effect of long-term TSH suppression on the development of sarcopenia and frailty in elderly patients with DTC.Method: Seventy patients aged 60 years and older with stable TSH levels during the last year and under L-T4 due to DTC were included in the...

Introduction: The prevalence of cardiometabolic disorders such as type 2 diabetes mellitus, dysipidemia and metabolic syndrome is increased in patients with Klinefelter syndrome (KS). The mechanism by which cardiometabolic risk increases in patients with KS remains to be completely elucidated. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of KS.Methods: A total of 31 patients wi...

Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. The pathogenesis of increased cardio-metabolic risk in hypogonadal patients is not clear. Oxidative stress plays an important role in the pathogenesis of cardio-metabolic diseases. The aim of this study was to search for any difference of the oxidative stress parameters between in patients with hypogonadism and healthy controls.Materials and Methods: Thirty ...

Objective: Metabolic disorders are common in patients with hypogonadism. Testosterone replacement therapy (TRT) significantly improves symptoms of testosterone deprivation such as mood, libido or musculoscelatal power. However, whether the metabolic and cardiovascular risk is improved is not clearly known. We aimed to search for the metabolic and cardiovascular effects of TRT.Design: Prospective study, performed in the outpatient units of Gulhane Medical...

Metabolic disorders and cardiovascular events are increased in hypogonadism. Serum HDL composition is a better cardiovascular predictor than the HDL counts. However, there is no information about the HDL subfractions in patients with hypogonadism. We designed a prospective study to investigate the HDL subfractions in treatment naïve subjects with hypogonadism and the effects of two different testosterone replacement regimens on the HDL subfractions. Seventy young male pat...

Introduction: Elevated depressive symptoms and depressive disorders affect one in four patients with type 1 or type 2 diabetes (1). Thus, routine screening for depressive symptoms is indicated in this high-risk population. Current guidelines all recommend screening for depression in diabetic population(2). The Patient Health Questionnaire-9 (PHQ-9) is a valid screening tool for depression in individuals with diabetes (3). There is no specific data about the prevalence of depre...